Solid acidic FeCl3/Bentonite catalyzed solvent-free condensation: Synthesis, spectral studies and antimicrobial activities of some aryl hydrazine Schiff’s bases

Vadamalai Ananthi, Kaliyaraj Rajalakshmi, Inbasekaran Muthuvel, Ganesamoorthy Thirunarayanan

Abstract


Some aryl hydrazide derivatives have been synthesized including 1-(3-chloro-4-nitrophenyl)-2-(3-substituted benzylidene) hydrazines by  FeCl3/Bentonite catalyzed solvent-free  condensation of  substituted phenyl hydrazine and aldehydes under microwave irradiation.  The yields of the hydrazides are more than 70%.  The synthesized hydrazides are characterized by the physical constants, micro analysis and spectroscopic data.  Effect of catalyst,  solvent effect  substituent effect and optimization of the catalyst was studied by the percentage of isolated yields.  From the catalyst optimization, the present study catalyst gave the better yield of products.  The antimicrobial activities of all synthesized of 1-(3-chloro-4-nitrophenyl)-2-(3-substituted benzylidene) hydrazines have been evaluated using Bauer-Kirby disc diffusion method.


Full Text:

PDF

References


G. Rajitha, N. Saideepa and P. Praneetha, Indian J. Chem., 50, 729 (2011)

R. Vijayakumar, M. Rajarajan, S. Balaji, V. Manikandan, R. Senbagam, G. Vanangamudi and G. Thirunarayanan, World Scientific News., 3, 81 (2015)

M Rajarajan, R Senbagam, R Vijayakumar, S Balaji, R Manikandan, G Vanangamudi and G Thirunarayanan, Indian J. Chem., 55B, 197 (2016)

M. Rajarajan, R. Senbagam, R. Vijayakumar, V. Manikandan, S. Balaji, G. Vanangamudi and G. Thirunarayanan, World Scientific News., 3, 155 (2015)

M. Rajarajan, S. Balaji, R. Vijayakumar, R. Senbagam, V. Manikandan, G. Vanangamudi and G. Thirunarayanan, JSM Chem., 4(1), 1021, Accepted and in press. (2016)

I. Asri, M. H. S. A. Hamid, A. H. Mirza, M. A. Alia and M.zaul Karimb, Acta Cryst., E70, o633 (2014)

J. P. Jasinski, A. N. Braley, C. S. C. Kumar, H. S. Yathirajan and A. N. Mayekarc, Acta Cryst., E67, o1200 (2011)

M. González, Y. Alvarado, J. Restrepo anad J. B. Colmenárez, Avances en Química., 8(3), 167 (2013)

S. R. Desai, U. V. Laddi, R. S. Bennur and S. C. Bennur, Indian J. Pharm. Sci., 2, 478 (2011)

S. I. Kovalenko, L. M. Antypenko, A. K. Bilyi, S. V. Kholodnyak, O. V. Karpenko, O. M. Antypenko, N. S. Mykhaylova, T. I. Los and O. S. Kоlоmоеts, Sci Pharm., 81, 359 (2013)

S. M. Patil, N. K. Tadge, P. S. Hargunani, V. J. Kadam and M. P. Toraskar, Indo Am. J. Pharm. Res., 4, 3188 (2014)

R. Dua and S. K. Srivatsava, Int. J. Pharm. Bio. Sci., 6, 1 (2010)

B. Parashar, S. Bharadwaj, V. K. Sharma and P. B. Punjabi, Der Pharma Chemica., 2(2), 229 (2010)

D.S. Salunkhe and P.B. Piste, Int. J. Pharm. Sci. Res., 5, 666 (2014)

R. Kumar, M. S. Yar, S. Chaturvedi and A. Srivastava, Pharm. Tech., 5,1844 (2013)

M. S. Saini, R. Singh, J. Dwivedi and Aran kumar, Int. J. Sci. Nature., 3, 925 (2012)

M. Asif, Int. J. Adv. Chem., 2, 85 (2014)

M. Molnar and M. Cacic, Croat. J. Food Sci. Technol., 4, 54 (2012)

A. Almasirad, S. S. Sadr and A. Shafiee, Iranian J. Pharm. Res., 10, 727 (2011)

K. Sheeja Devi, Y. Swapna, S. Bhagya Lakshmi, M. Suchitra, G. Sivakumar, K. Srinivasulu, A. J. Res. Pharm. Sci. Biotech., 1, 1 (2013)

L. P. Lv, X. F. Zhou, H. B. Shic, J. R. Gaoa and W. X. Hu, J. Chem. Res., 38, 368 (2014)

A. M. Mocanu, C. Cernatescu, Sci. Res., 8, 437 (2007)

S. Nain, A. Sharma, H. Singh and S. Paliwal, J. Biomed. Ther. Sci., 2, 1 (2015)

E. H. M. Hussein, A. A. E. Adasy, I. S. A. Hafi , E. A. Ishak, E. H. Gawish and M. S. A. E. Gaby, J. App. Pharm., 6, 296 (2014)

A. Almasirad, S. S. Sadr and A. Shafiee, Iranian J. Pharm. Res., 10, 727 (2011)

B. N. Prasanna Kumar, K. N. Mohanaa, L. Malleshab and N. D. Rekhac, Curr. Chem. Lett., 2, 176 (2013)

R. Vijayakumar, R. Senbagam, M. Rajarajan, S. Balaji, V. Manikandan, G. Vanangamudi and G Thirunarayanan, Annales Univ. Mariae Curie-Skłodowska, Lublin – Polonia, 70(2), 103 (2015)

A. W. Bauer, W. M. M. Kirby, J. C. Sherris and M. Truck, Am. J. Clin. Pathol., 45, 493 (1966)

I. Muthuvel, S. Dineshkumar, K. Thirumurthy, B. Krishnakumar and G. Thirunarayanan, Indian J. Chem., 55B, 252-260 (2016)

G. Thirunarayanan, J. Pharm. Appl. Chem., 3(1), (2017) Accepted and in Press.

G. L. Regina, V. Gatti, F. Pisciteilli, R. Silvestri, ACS Comb. Sci., 13, 2 (2011)

G. Nagalakshmi, T. K. Maity and B. C. Maiti, Der Pharmacia Lett., 5 (2), 165(2013)

K. Eloh, M. Demurtas, A. Deplano, A. N. Mfopa, A. Murgia, A. Maxia, V. Onnis and P. Caboni, J. Agric. Food Chem.,

M. Rajarajan, R. Vijayakumar, R. Senbagam, S. Balaji, V. Manikandan, G. Vanangamudi, and G. Thirunarayanan, Int. Lett. Chem., Phys. Astro. 59, 147 (2015)

M. Rajarajana, R. Vijayakumar, S. Balaji, R. Senbagam, V. Manikandan, G. Vanangamudi, G. Thirunarayanan, Orbital: The Electronic J. Chem., 8(5), 288 (2016)




DOI: http://dx.doi.org/10.17951/aa.2016.71.2.127
Date of publication: 2017-04-03 12:28:05
Date of submission: 2016-11-14 05:53:44


Statistics


Total abstract view - 765
Downloads (from 2020-06-17) - PDF - 553

Indicators



Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Ganesamoorthy Thirunarayanan